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apalutamide will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications that are CYP3A4 substrates may result in reduced exposure to these drugs.Observe Intently (one)modafinil will boost the